Protein power strokes
نویسنده
چکیده
How is dynamic instability regulated? Some microtubuleassociated proteins, or MAPs, can attach along the sides of the microtubules, slowing or reversing shrinkage. These MAPs are dominant in interphase cells and neurons, which is why microtubules in these cells are not very dynamic. Other MAPs, dominant in mitosis, attach to microtubule ends, where they can stabilize or destabilize microtubules by changing the frequencies of transitions between growing and shrinking states. The activity of many of these MAPs is highly regulated in time and in space.
منابع مشابه
Dimeric heat shock protein 40 binds radial spokes for generating coupled power strokes and recovery strokes of 9 + 2 flagella
T-shape radial spokes regulate flagellar beating. However, the precise function and molecular mechanism of these spokes remain unclear. Interestingly, Chlamydomonas reinhardtii flagella lacking a dimeric heat shock protein (HSP) 40 at the spokehead-spokestalk juncture appear normal in length and composition but twitch actively while cells jiggle without procession, resembling a central pair (CP...
متن کاملA novel crustacean swimming stroke: coordinated four-paddled locomotion in the cypridoidean ostracode Cypridopsis vidua (Müller).
Despite the diversity and ecological importance of cypridoidean ostracodes, there have been no kinematic studies of how they swim. We used regular and high-speed video of tethered ostracodes to document locomotion in the cypridoidean species Cypridopsis vidua. Swimming in this species is drag-based, with thrust provided by both antennulae and antennae. About 15 complete power and recovery strok...
متن کاملBidirectional power stroke by ncd kinesin.
Optical trapping experiments reveal details of molecular motor dynamics. In noisy data, temporal structure within the power stroke of motors can be analyzed by ensemble averaging, but this obscures infrequent subcategories of events. We have here developed an analysis method that uses Kalman filtering of measurements, model-based estimation of the power strokes produced by the motor head, and a...
متن کاملMechanochemistry of a viral DNA packaging motor.
The pentameric ATPase motor gp16 packages double-stranded DNA into the bacteriophage phi29 virus capsid. On the basis of the results of single-molecule experimental studies, we propose a push and roll mechanism to explain how the packaging motor translocates the DNA in bursts of four 2.5 bp power strokes, while rotating the DNA. In this mechanism, each power stroke accompanies P(i) release afte...
متن کاملPerformance of Surge Arrester to Multiple Lightning Strokes on Nearby Distribution Transformer
Overhead distribution lines are prone to lightning overvoltages due to their configurations and characteristics. Metal Oxide Varistor (MOVs) arresters for many years have proven to be more advantageous than others arresters in lightning surge protection; therefore it is worthwhile to continually assess the behavior and performance of these arresters to different kind of overvoltages caused by l...
متن کاملRole of proprioceptive feedback from nonspiking mechanosensory cells in the sand crab, Emerita analoga.
The two programmes underlying uropod beating in Emerita ('swimming' and 'treading water') are distinguished by a difference in timing of the power stroke within the interval between return strokes (cycle). While 'swimming' (cycles approx. 80-400 ms) the phase and while 'treading water' (cycles approx. 100-700 ms) the latency of the power stroke are relatively invariant. Analyses of electromyogr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006